I'm not a huge fan of American Football, but this article in The New York Times shows a fascinating development of how the game can be played.
From what I understand, the "standard" situation of two lines of big blokes facing off at one another and then having a group hug while someone else throws a ball backwards is being challenged by this new structure. The picture above (which is from the NYT article) shows the potential of the A-11 formation.
Basically put, the A-11 formation allows any player to become the Quarterback. This sort of formation, according to the NYT, allows 16,632 different scenarios of play, compared with 36 scenarios if done the "traditional" way.
The A-11 formation seems to also create a new breed of player - quick and fit as opposed to huge and inertial. This will also breed a new type of play, which will increase the speed at which the game travels.
As an outsider from Australia, I can't help but see this development as being comparable to Rugby Union and Rugby League. Both games, popular and profitable here in Australian and in other nations, reward teams that are quick and creative.
I personally think that this will bring about a sea change in American Football, so long as the rules don't end up being changed to prevent it.